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Cytokines in psoriasis: From pathogenesis to targeted therapy
1Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders and Department of Molecular Medicine, Arabian Gulf University, Manama, Bahrain.
Human Immunology
|May 20, 2024
Summary
Psoriasis, a complex skin disease, involves immune system imbalances and environmental triggers. Understanding cytokine roles, like T-helper 17 cells, is key to developing effective psoriasis treatments.
Area of Science:
- Immunodermatology
- Genetics
- Molecular Biology
Background:
- Psoriasis affects 0.84% globally, presenting with scaly lesions.
- Initially viewed as a keratinocyte disorder, it's now recognized as multifactorial.
- Genetic predisposition interacting with immunological and environmental factors drives psoriasis.
Purpose of the Study:
- To comprehensively review the role of cytokines in psoriasis pathogenesis.
- To highlight controversies and connections between cytokine imbalance and disease manifestations.
- To present current and investigational targeted psoriasis treatments.
Main Methods:
- Review of existing literature on psoriasis immunology and cytokine involvement.
- Analysis of the historical understanding and evolution of psoriasis research.
- Identification of key cytokines and their pathways implicated in psoriasis.
Main Results:
- Cytokines, particularly those from T-helper 17 (Th17) cells, are crucial in psoriasis.
- Initial understanding focused on type-1 immunity cytokines (interferon-γ, interleukin-2, interleukin-12).
- Advancements in understanding Th17 cells have led to targeted biological therapies.
Conclusions:
- Cytokine dysregulation is central to psoriasis development and manifestation.
- Targeted therapies focusing on specific cytokines have revolutionized psoriasis treatment.
- Ongoing research continues to explore novel cytokine-based therapeutic strategies for psoriasis.
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