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Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
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Published on: August 7, 2018

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MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis

Shuzhen Liu1, Preston Perez2, Xue Sun1,3

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.

Cell Death and Differentiation
|November 23, 2023
PubMed
Summary

Mixed lineage kinase-like protein (MLKL) polymerization triggers cell death by causing lysosomal membrane permeabilization. This releases cathepsin B (CTSB), a key enzyme driving necroptosis.

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