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Development of a Screening Method for Fluoroquinolones in Meat Samples Using Molecularly Imprinted Carbon Dots
Ahmed Faried Abdel Hakiem1,2, Idoia Urriza-Arsuaga3, Javier L Urraca2
1Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt.
Biosensors
|November 24, 2023
Summary
A new method uses fluorescent carbon dots and imprinted polymers to detect fluoroquinolone antibiotics in food. This simple, accurate screening tool helps monitor environmental contamination and ensure food safety.
Area of Science:
- Analytical Chemistry
- Materials Science
- Environmental Science
Background:
- Fluoroquinolone antibiotics are widely used in veterinary medicine, leading to potential environmental contamination and food residues.
- Accurate and sensitive detection methods are crucial for monitoring fluoroquinolone levels in food and environmental samples.
Purpose of the Study:
- To develop a simple, accurate, and sensitive screening method for fluoroquinolone antibiotics.
- To create novel fluorescent polymeric composites for enhanced detection capabilities.
Main Methods:
- Synthesis of carbon dots via hydrothermal treatment for use as fluorescent nano-sensors.
- Development of organic-based molecularly imprinted polymers using enoxacin as a template.
- Optimization of the fluorescence-based detection method for pH and composite concentration.
Main Results:
- The developed method demonstrated efficient fluorescence quenching upon fluoroquinolone addition, with excellent correlation coefficients (0.65-0.992).
- Achieved excellent detection and quantification limits for fluoroquinolones (down to 0.062 and 0.186 mg L⁻¹, respectively).
- Successfully applied the method to determine enrofloxacin in beef, pork, and chicken samples with good recovery rates (70-100%).
Conclusions:
- The proposed method offers a simple and effective approach for screening fluoroquinolone antibiotics.
- This technique is valuable for monitoring environmental hazards and ensuring quality control in food safety applications.
- The fluorescent polymeric composites show promise for sensitive and selective detection of various fluoroquinolones.
