Synthesis and characterization of piroxicam and M (M = Pd(II), Ag(I)) complex nanoconjugates with orange quantum dots...

Conjugation and loading of piroxicam and its metal complexes; Palladium(II) (PdL) and Silver(I) (AgL) synthesized and characterized by different techniques including infrared, UV-Vis spectroscopy, spectrofluorimetry, transmission electron microscope, x-ray powder diffraction and Zeta potential analyses were achieved. Orange quantum dots (OQDs) nanoparticle showed good stability, encapsulation and loading efficiency and controlled release of loaded piroxicam and its metal complexes. Generally, new OQQs conjugates showed enhanced antimicrobial and anticancer activity.In vitroantimicrobial activity screening demonstrated thatAg(I)-OQDs conjugate displayed potent antibacterial effect that was 1.8-fold againstE. colihigher than piroxicam (MIC = 31.85µM), wherePd(II)-OQDs conjugate depicted the highest activity with MIC of 33.05µM againstP. aeruginosa. In case of G + ve bacteria,Agconjugate had potent activity which was 2.3-fold onS. aureushigher than piroxicam (MIC = 43.12µM), whilePdconjugate exerted promising activity that was 3.5-fold againstE. faecalishigher than piroxicam (MIC = 74.57µM).Agconjugate showed the most promising antifungal activity with 2.5-folds more than piroxicam. Thein vitroantiproliferative activity depicted that all synthesized conjugates showed better Cytotoxic effect than piroxicam, specificallyPdconjugate which had IC50 values with by 2-fold lower than piroxicam on human liver cancer cell lineHepg2.WhilePdandAgconjugates showed 2.3 and 1.9-fold higher effect on human colon cancer cell lineHT-29compared to piroxicam.