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TEM8 in Oncogenesis: Protein Biology, Pre-Clinical Agents, and Clinical Rationale
Samuel A Kareff1, Virginia Corbett2, Paul Hallenbeck3
1University of Miami Sylvester Comprehensive Cancer Center/Jackson Memorial Hospital, Miami, FL 33136, USA.
Abstract:
The TEM8 protein represents an emerging biomarker in many solid tumor histologies. Given the various roles it plays in oncogenesis, including but not limited to angiogenesis, epithelial-to-mesenchymal transition, and cell migration, TEM8 has recently served and will continue to serve as the target of novel oncologic therapies. We review herein the role of TEM8 in oncogenesis. We review its normal function, highlight the additional roles it plays in the tumor microenvironment, and synthesize pre-clinical and clinical data currently available. We underline the protein's prognostic and predictive abilities in various solid tumors by (1) highlighting its association with more aggressive disease biology and poor clinical outcomes and (2) assessing its associated clinical trial landscape. Finally, we offer future directions for clinical studies involving TEM8, including incorporating pre-clinical agents into clinical trials and combining previously tested oncologic therapies with currently available treatments, such as immunotherapy.
Insights
The TEM8 protein is a promising biomarker and therapeutic target in solid tumors. Its roles in cancer progression and association with poor outcomes highlight its potential in novel oncologic therapies and clinical trials.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- Tumor Endothelial Marker 8 (TEM8) is increasingly recognized as a significant biomarker in various solid tumors.
- TEM8 plays crucial roles in oncogenesis, including angiogenesis, epithelial-to-mesenchymal transition, and cell migration.
- Its involvement in the tumor microenvironment suggests a multifaceted role in cancer progression.
Purpose of the Study:
- To review the normal function and oncogenic roles of the TEM8 protein.
- To synthesize available pre-clinical and clinical data on TEM8.
- To evaluate TEM8's prognostic and predictive value and its clinical trial landscape.
Main Methods:
- Literature review of pre-clinical and clinical studies on TEM8.
- Analysis of TEM8's association with tumor biology and clinical outcomes.
- Assessment of the current clinical trial landscape for TEM8-targeted therapies.
Main Results:
- TEM8 is linked to aggressive disease biology and poorer clinical outcomes across multiple solid tumors.
- The protein is a target for novel oncologic therapies, with an active clinical trial landscape.
- TEM8's prognostic and predictive capabilities are significant in understanding cancer progression.
Conclusions:
- TEM8 is a critical player in oncogenesis and a valuable biomarker for solid tumors.
- Further clinical studies are warranted to explore TEM8-targeting agents and combination therapies, including immunotherapy.
- Understanding TEM8's role can guide the development of new cancer treatments.
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