A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis

Area of Science:

• Biochemistry
• Oral Health
• Nutritional Science

Background:

• Vitamin K2 (VK2) is crucial for bone metabolism.
• Limited data exists on the relationship between VK2 and periodontitis.

Purpose of the Study:

• To investigate the potential association between serum VK2 levels and periodontitis severity.
• To compare VK2 levels in periodontitis patients versus healthy individuals.

Main Methods:

• 100 participants (50 with periodontitis) underwent clinical and radiological periodontal assessments.
• Serum VK2 levels were measured using ELISA kits.
• Statistical analysis compared VK2 levels between groups and correlated them with clinical parameters.

Main Results:

• Periodontitis patients exhibited significantly lower mean serum VK2 levels (0.27 nmol/L) compared to controls (0.43 nmol/L).
• VK2 levels decreased progressively with increasing periodontitis severity (Stage IV: 0.19 nmol/L).
• Lower VK2 levels correlated significantly with increased bleeding on probing, attachment loss, and bone loss.

Conclusions:

• Serum VK2 levels are significantly lower in individuals with periodontitis.
• Reduced VK2 is associated with the severity and clinical manifestations of periodontitis.
• Further research may explore VK2 supplementation for periodontitis management.