Dynamic Contrast-Enhanced Study in the mpMRI of the Prostate-Unnecessary or Underutilised? A Narrative Review

Area of Science:

• Radiology
• Oncology
• Medical Imaging

Background:

• Multiparametric MRI (mpMRI) is crucial for prostate cancer detection.
• Dynamic Contrast-Enhanced MRI (DCE-MRI) provides functional information on vascularity and permeability.
• The clinical utility of DCE-MRI in prostate cancer assessment is under continuous investigation.

Purpose of the Study:

• To review recent literature on the clinical application of DCE-MRI in prostate cancer.
• To summarize the principles of DCE-MRI acquisition and analysis.
• To evaluate the advantages and disadvantages of DCE-MRI in current practice and categorization systems.

Main Methods:

• Comprehensive literature search on DCE-MRI for prostate cancer.
• Analysis of studies on DCE-MRI's role in PI-RADS categorization.
• Review of data comparing DCE-MRI with biparametric MRI (bpMRI) and mpMRI.

Main Results:

• DCE-MRI offers valuable insights into lesion vascularity and permeability.
• Current PI-RADS categorization shows limitations in fully utilizing DCE-MRI.
• Debate exists regarding the routine use of gadolinium-based contrast agents in prostate MRI.

Conclusions:

• DCE-MRI has significant potential for improving prostate cancer diagnosis and monitoring.
• Optimizing DCE-MRI's integration into mpMRI protocols may enhance sensitivity and specificity.
• Further research is warranted to establish standardized protocols and clarify its role in clinical decision-making.