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Updated: Jun 22, 2025

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Enucleation of the Prostate for the Treatment of Benign Prostatic Hyperplasia Using a 980 nm Diode Laser
Published on: May 5, 2020
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THULIUM:YAG LASER ENUCLEATION OF THE PROSTATE (ThuLEP) - OUR EXPERIENCE IN 246 PATIENTS
Nikola Zebić1, Velimir Terzić2,3, Vinko Krajina4,3
1Department of Urology, Hospital Rotthalmünster, Health facilities District of Passau, Germany.
Acta Clinica Croatica
|July 5, 2024
Summary
Thulium:YAG laser enucleation of the prostate (ThuLEP) offers a safe and effective minimally invasive treatment for benign prostatic hyperplasia (BPH). This procedure significantly improves urinary symptoms and reduces prostate size, regardless of gland volume.
Area of Science:
- Urology
- Minimally Invasive Surgery
- Laser Technology
Background:
- Benign prostatic hyperplasia (BPH) is a common condition requiring treatment.
- Traditional surgical methods for BPH have limitations, particularly for large prostates.
- Minimally invasive laser techniques have emerged as alternatives.
Purpose of the Study:
- To evaluate the experience and outcomes of thulium:YAG laser enucleation of the prostate (ThuLEP) for BPH treatment.
- To assess the safety, efficacy, and invasiveness of ThuLEP.
Main Methods:
- Retrospective analysis of 246 patients undergoing ThuLEP over five years.
- Complete urologic evaluation prior to surgery.
- Detailed recording of surgical parameters, complications, and postoperative outcomes.
Main Results:
- Mean patient age was 73 years; mean surgery duration was 92 minutes.
- Mean enucleated tissue weight was 73 grams.
- Low complication rates, short hospital stay, significant improvement in urodynamic parameters, and reduced post-void residual urine volume were observed.
Conclusions:
- ThuLEP is a safe and efficient surgical method for BPH treatment.
- The procedure is not limited by prostate size and demonstrates minimal invasiveness.
- ThuLEP shows potential to replace current standard surgical procedures for BPH.

