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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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A Macrophage-Tumor Spheroid Co-Invasion Assay
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Macrophage-Based Microrobots for Anticancer Therapy: Recent Progress and Future Perspectives.

Van Du Nguyen1,2, Jong-Oh Park2, Eunpyo Choi1,2,3

  • 1Robot Research Initiative, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.

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Summary

Macrophage-based microrobots offer a novel "Trojan horse" strategy for cancer therapy by targeting tumors. This review details their development, targeting methods, and diverse therapeutic applications.

Keywords:
anticancerbiomedical applicationcell microrobotdrug deliverymacrophagemagneticphotothermaltumor targeting

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Macrophages, part of the mononuclear phagocytic system, possess inherent tumor-targeting capabilities.
  • Their phagocytic nature suggests a "Trojan horse" approach for drug delivery by engulfing drug-loaded particles.

Purpose of the Study:

  • To review recent advancements in macrophage-based microrobots for anticancer therapy.
  • To discuss the components, targeting strategies, and applications of these novel therapeutic agents.

Main Methods:

  • Review of current literature on macrophage-based microrobot development.
  • Analysis of macrophage cell types, payloads, and targeting mechanisms (biological, chemical, acoustic, magnetic).

Main Results:

  • Macrophage microrobots demonstrate potential in various cancer treatment modalities.
  • Applications include photothermal therapy, chemotherapy, immunotherapy, and combination therapies.

Conclusions:

  • Macrophage-based microrobots represent a promising frontier in cancer therapy.
  • Further development is expected to enhance their clinical applicability and efficacy.