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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...

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Related Experiment Video

Updated: Jul 1, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Parametric Rule-Based Intelligent System (PRISM) for Design and Analysis of High-Strength Separable Microneedles.

Sanghwi Ju1,2,3, Seung-Hyun Im3, Kyungsun Seo4

  • 1Graduate School of Data Science, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.

Micromachines
|July 30, 2025
PubMed
Summary

A new system called PRISM designs high-strength separable microneedles for painless transdermal drug delivery. This system enables robust skin penetration and reliable detachment, outperforming conventional designs.

Keywords:
drug deliverymechanical strengthmicro-3D printingparametric designseparable microneedles

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Biomedical Engineering

Background:

  • Transdermal microneedle systems offer minimally invasive delivery of biomolecules with reduced pain.
  • Designing microneedles with high strength for easy skin penetration and patch detachment remains a challenge.

Purpose of the Study:

  • To develop a Parametric Rule-based Intelligent System (PRISM) for designing and analyzing high-strength separable microneedles.
  • To create microneedle systems that achieve both robust skin penetration and reliable separable delivery.

Main Methods:

  • Integration of parametric 3D modeling, geometry-based structural analysis, and micro-3D printing (pµSL).
  • Fabrication of prototype microneedle arrays using pµSL.
  • Mechanical testing and evaluation in skin-mimicking phantom samples.

Main Results:

  • PRISM-designed microneedles demonstrated superior mechanical properties: 2.13 ± 0.51 N axial resistance and 73.92 ± 34.77 mN shear fracture force.
  • Successful separation of microneedle tips in a skin-mimicking phantom.
  • PRISM designs achieved target depth insertion and separation, unlike conventional designs that failed.

Conclusions:

  • The PRISM platform enables the creation of high-strength separable microneedles.
  • This approach offers an efficient tool for developing advanced transdermal drug delivery technologies.
  • The developed microneedles show promise for improved therapeutic efficacy and patient compliance.