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Updated: Jul 10, 2025

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
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Limb Amputations in Cancer: Modern Perspectives, Outcomes, and Alternatives.

Thien Huong N Huynh1, Davis R Kuruvilla1, Matthew D Nester1

  • 1University of South Florida Health Morsani College of Medicine, Tampa, FL, USA.

Current Oncology Reports
|November 24, 2023
PubMed
Summary

Limb amputation in cancer care, particularly for bone cancers, is evolving. Modern techniques like rotationplasty and osseointegration offer improved outcomes, alongside advances in nerve interfaces for better prosthesis control.

Keywords:
AmputationOsseointegrationOsteosarcomaRegenerative peripheral nerve interfacesRotationplastyTargeted muscle reinnervation

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Area of Science:

  • Oncology
  • Orthopedics
  • Rehabilitation Medicine

Background:

  • Limb amputation has a long history in cancer treatment, especially for bone malignancies.
  • While limb-sparing surgeries are common, amputation remains a vital option for complex cases and palliative care.

Purpose of the Study:

  • To review current applications of limb amputation in cancer management.
  • To explore advancements in limb-sparing techniques and amputation-related technologies.

Main Methods:

  • Literature review of recent findings on amputation and limb-sparing surgery in oncology.
  • Analysis of emerging techniques such as rotationplasty, osseointegration, targeted muscle reinnervation (TMR), and regenerative peripheral nerve interfaces (RPNI).

Main Results:

  • New techniques like rotationplasty and osseointegration show promise for better functional outcomes.
  • Targeted muscle reinnervation (TMR) and regenerative peripheral nerve interfaces (RPNI) enhance prosthetic control.
  • Amputation serves as a critical palliative or primary treatment for complex bone cancers.

Conclusions:

  • Contemporary cancer management integrates advanced amputation techniques and limb-sparing strategies.
  • Innovations in prosthetics and nerve interfaces are improving quality of life for amputees.
  • Further research is needed to optimize functional recovery and patient outcomes in limb cancer treatment.