Related Experiment Video
Updated: Jul 10, 2025

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
Aging Skin and Wound Healing
Michael Kremer1, Nicole Burkemper1
1Department of Dermatology, SSM Saint Louis University Hospital, 1225 South Grand Boulevard 3L, St. Louis, MO 63104, USA.
Abstract:
Responsible for many essential functions of life, human skin is made up of many components, each of which undergoes significant functional changes with aging and photodamage. Wound healing was previously thought to be defective in the elderly given the higher presence of chronic wounds and the longer time required for re-epithelialization of acute wounds. However, these notions have been challenged in recent research, which has shown that wound healing in the elderly is delayed but not defective. Poor healing of chronic wounds in older populations is more often attributable to comorbid conditions rather than age alone.
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