P-suPAR may reflect the inflammatory response after pancreatic surgery
Anu Aronen1, Janne Aittoniemi2, Reetta Huttunen3
1Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Finland; Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland.
Summary
Plasma soluble urokinase plasminogen activator receptor (P-suPAR) levels decrease after pancreatic surgery. Lower P-suPAR on postoperative day 1 indicates complications like pancreatic fistula, pancreatitis, or surgical site infection.
Area of Science:
- Biomarker research
- Surgical oncology
- Inflammatory response studies
Background:
- Existing scoring systems for post-pancreatectomy complications have limited predictive value.
- Current inflammatory markers are insufficient for predicting complications after pancreatic surgery.
- Plasma soluble urokinase plasminogen activator receptor (P-suPAR) is a prognostic biomarker in inflammatory conditions.
Purpose of the Study:
- To investigate P-suPAR levels in patients before and after pancreatic surgery.
- To assess the correlation between P-suPAR levels and postoperative complications.
Main Methods:
- 176 patients undergoing pancreatic surgery for suspected malignant or premalignant lesions were recruited.
- P-suPAR levels were analyzed preoperatively and on postoperative days 1 and 3.
- Comparison of P-suPAR levels between patients with and without specific postoperative complications.
Main Results:
- P-suPAR levels significantly decreased from preoperative values on postoperative days 1 and 3.
- Lower P-suPAR on postoperative day 1 was observed in patients who developed postoperative pancreatic fistula (POPF).
- Similar decreases in P-suPAR were noted in patients with postoperative acute pancreatitis (POAP) and surgical site infection (SSI).
Conclusions:
- Postoperative day 1 P-suPAR levels are significantly lower in patients experiencing POPF, POAP, or SSI.
- A general decrease in P-suPAR is observed in all patients following pancreatic resection.
- This postoperative P-suPAR profile may indicate a compensatory anti-inflammatory response post-surgery.
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