Related Experiment Video
Updated: Jul 10, 2025
10:25
In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
Published on: February 4, 2015
9.8K
Gut-Kidney-Heart: A Novel Trilogy
Mario Caldarelli1, Laura Franza2, Pierluigi Rio1
1Department of Translational Medicine and Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of Rome, 00168 Rome, Italy.
Biomedicines
|November 25, 2023
Summary
The gut microbiota influences health and disease, potentially mediating the gut-kidney-heart axis. This review explores the gut microbiota
Area of Science:
- Microbiology and Systems Biology
- Gut-Kidney-Heart Axis Research
Background:
- The gut microbiota plays a crucial role in maintaining health and influencing various diseases.
- Its involvement extends beyond inflammation to complex conditions affecting neurological, psychiatric, gastrointestinal, and cardiovascular systems.
- A novel hypothesis suggests the gut microbiota acts as a mediator in the gut-kidney-heart axis.
Purpose of the Study:
- To review the impact of gut microbiota on the kidney and cardiovascular systems.
- To examine the evidence supporting the gut-kidney-heart axis.
- To discuss the role of gut metabolites and potential therapeutic strategies.
Main Methods:
- Narrative review of existing scientific literature.
- Analysis of data on gut microbiota's influence on individual organ systems.
- Synthesis of evidence pertaining to the gut-kidney-heart axis.
Main Results:
- The gut microbiota significantly impacts kidney and cardiovascular health.
- Emerging data supports the concept of a gut-kidney-heart axis.
- Gut metabolites are identified as key players in this intricate relationship.
Conclusions:
- The gut microbiota is integral to the gut-kidney-heart axis, influencing interconnected organ health.
- Understanding this axis opens avenues for novel therapeutic interventions targeting gut metabolites.
- Further research is warranted to fully elucidate the mechanisms and therapeutic potential.
Related Concept Videos
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
436
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
436
01:45Kidney Structure
69.8K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
69.8K
01:29Renal Regulation of Acid-Base Balance
468
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
468
01:27Development of the Heart
964
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
964
01:12Internal Anatomy of the Kidney
1.8K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.8K
01:18Blood and Nerve Supply to the Kidney
1.1K
The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of...
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of...
1.1K