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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian

Young Lee1,2, Je Hyun Seo1

  • 1Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul 05368, Republic of Korea.

Biomolecules
|November 25, 2023
PubMed
Summary

Elevated gamma-glutamyl transferase (GGT) levels show a causal link to stroke risk. This study suggests GGT may be a significant potential risk factor for stroke, warranting further investigation.

Keywords:
alcoholatrial fibrillationbody mass indexgamma-glutamyl transferasemendelian randomizationsingle-nucleotide polymorphismsstroke

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Area of Science:

  • Genetics
  • Epidemiology
  • Cardiovascular Medicine

Background:

  • A potential association between gamma-glutamyl transferase (GGT) levels and stroke has been proposed.
  • Understanding the causal relationship is crucial for stroke prevention strategies.

Purpose of the Study:

  • To investigate the potential causal relationship between gamma-glutamyl transferase (GGT) levels and stroke, including its subtypes.
  • To assess GGT as a potential risk factor for stroke in a European population.

Main Methods:

  • A two-sample Mendelian randomization (MR) study was conducted using genome-wide association study (GWAS) data.
  • UK Biobank data served as the exposure set for GGT levels, and GIGASTROKE Consortium data for stroke outcomes.
  • Multivariable MR and PhenoScanner were employed to adjust for confounders like alcohol consumption, atrial fibrillation, and body mass index.

Main Results:

  • Significant causal associations were observed between GGT levels and stroke (IVW: OR=1.23, p=0.012; MR-PRESSO: OR=1.19, p=0.031).
  • Results remained consistent after removing single nucleotide polymorphisms (SNPs) linked to confounding factors.
  • Multivariable MR analysis confirmed GGT's association with stroke after adjusting for confounders (OR=1.30, p=0.010).

Conclusions:

  • Gamma-glutamyl transferase (GGT) level demonstrates a causal relationship with stroke.
  • GGT should be evaluated as a potential risk factor for stroke.
  • Further research is necessary to validate these findings and their clinical implications.