Nutritional Approach in Selected Inherited Metabolic Cardiac Disorders-A Concise Summary of Available Scientific
Alina Costina Luca1, Ioana-Alexandra Pădureț1,2, Viorel Țarcă3
1Pediatrics Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Nutrients
|November 25, 2023
Summary
Dietary interventions show promise for inborn errors of metabolism (IMDs) impacting the heart. Further research is needed to determine optimal diets and imaging for cardiovascular monitoring in these rare genetic disorders.
Area of Science:
- Cardiology
- Metabolic Disorders
- Nutritional Science
Background:
- Inborn errors of metabolism (IMDs) can cause significant cardiovascular damage.
- Current IMD therapies include enzyme replacement, supplements, and specialized diets.
- Pediatric cardiologists identify cardiomyopathies, conduction disorders, and valvular dysplasias as key indicators of IMDs.
Purpose of the Study:
- To explore dietary interventions for improving cardiovascular outcomes in patients with mitochondrial and lysosomal disorders.
- To highlight the need for evidence-based dietary recommendations for IMDs.
- To discuss imaging techniques for monitoring dietary impacts on cardiac function.
Main Methods:
- Review of current literature on dietary interventions for IMDs with cardiac manifestations.
- Analysis of the role of ketogenic and other diets in managing IMDs.
- Evaluation of echocardiography and cardiac MRI for cardiovascular assessment.
Main Results:
- Ketogenic diets show potential in specific IMD cases, but require more evidence for general use.
- The precise cardiac effects of various diets in IMDs are not fully understood.
- Echocardiography and Cardiac MRI offer valuable insights into diet-related cardiovascular changes.
Conclusions:
- Personalized dietary plans are crucial for managing IMDs with cardiac involvement.
- Prospective studies are essential to establish optimal diets and monitoring protocols for IMD-related cardiovascular conditions.
- Standardized imaging protocols are needed to assess the impact of diets on cardiac health.
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