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Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges
Mohamed M Ashour1, Mostafa Mabrouk2, Mohamed A Aboelnasr3
1School of Biotechnology, Badr University in Cairo, Badr City, Cairo 11829, Egypt.
Pharmaceutics
|November 25, 2023
Summary
Novel drug delivery systems (DDSs) offer promising, effective, and specific obesity treatments beyond traditional methods. Further research into DDS design is crucial for developing safe and efficient obesity management strategies.
Area of Science:
- Pharmacology and Materials Science
- Biomedical Engineering
Background:
- Obesity is a global epidemic with significant health and economic consequences, projected to affect 60% of the world's population by 2030.
- Traditional obesity treatments like pharmacotherapy and bariatric surgery have limitations, including side effects and suboptimal efficacy, necessitating alternative approaches.
- Emerging drug delivery systems (DDSs) utilizing polymeric materials and chemical strategies show potential for enhancing therapeutic effectiveness and specificity in obesity treatment.
Purpose of the Study:
- To provide a comprehensive review of current and conventional anti-obesity treatment strategies.
- To discuss the design and creation of drug delivery systems (DDSs) for obesity management.
- To address the knowledge gap concerning the intricate physical and chemical parameters influencing DDS effectiveness, including microneedle-based systems.
Main Methods:
- Literature review of existing anti-obesity therapeutics and emerging drug delivery systems.
- Analysis of the interplay between physical and chemical parameters in DDS design for obesity treatment.
- Exploration of advanced DDS techniques and their potential in preclinical (animal-study) and future clinical applications.
Main Results:
- Current literature lacks in-depth reviews focusing on the development and design of DDSs specifically for obesity treatment.
- The effectiveness of DDSs, including microneedles, is contingent upon a complex interplay of synthesis methods and physical/chemical properties.
- Advanced DDS techniques hold significant promise for developing safer and more efficient obesity treatments.
Conclusions:
- There is an urgent need for novel, effective, and specific obesity treatments.
- Drug delivery systems (DDSs) represent a key area of research for advancing obesity therapeutics.
- Further investigation into DDS design and synthesis is essential for realizing their full potential in managing obesity.
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