Multiplexing Quadrupole and Ion Trap Operation Modes on a "Brick" Miniature Mass Spectrometer

Area of Science:

• Analytical Chemistry
• Mass Spectrometry Instrumentation

Background:

• Quadrupole and ion trap mass analyzers offer complementary features but typically require separate instruments.
• Integrating diverse analytical capabilities into a single, compact system is a key goal in mass spectrometry development.

Purpose of the Study:

• To develop a single mass analyzer capable of operating in both quadrupole and ion trap modes.
• To enhance the analytical coverage and versatility of miniature mass spectrometers.

Main Methods:

• A printed circuit board (PCB)-based multi-electrode quadrupole-ion trap mass analyzer was designed and integrated.
• Two ionization sources, nano electrospray ionization and in-vacuum plasma ionization, were implemented for broad molecule analysis.
• The instrument's performance was characterized in both quadrupole and ion trap modes, assessing mass range, resolution, and sensitivity.

Main Results:

• The quadrupole mode successfully analyzed ions from 31 to 502 Th.
• The ion trap mode covered higher mass-to-charge ratios up to 922 Th and enabled tandem mass spectrometry.
• The integrated system demonstrated multiplexed operation of both quadrupole and ion trap modes.

Conclusions:

• The developed miniature mass spectrometer successfully combines quadrupole and ion trap functionalities within a single mass analyzer.
• This integration significantly extends the analytical capabilities and problem-solving potential for diverse chemical analyses.
• The PCB-based design and dual ionization sources contribute to a versatile and high-performance analytical instrument.