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Related Experiment Video

Updated: Jul 10, 2025

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
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Liquid Crystal Polymer-Based Miniaturized Fully Implantable Deep Brain Stimulator.

Seung-Hee Ahn1, Chin Su Koh2, Minkyung Park2

  • 1Department of Electrical and Computer Engineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.

Polymers
|November 25, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed a miniaturized, implantable deep brain stimulation (DBS) system for rats. This battery-free device, made from liquid crystal polymer (LCP), effectively reduced neuropathic pain in animal models.

Keywords:
deep brain stimulationimplantable electronicsliquid crystal polymersvon Frey test

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • Deep brain stimulation (DBS) systems face challenges in miniaturization for reduced invasiveness.
  • Integrating stimulators and electrodes into compact, wireless-charging units is crucial for advanced DBS.
  • Current DBS systems often require bulky external components or batteries, limiting animal behavior.

Purpose of the Study:

  • To develop a miniaturized, fully implantable, and battery-free DBS system for preclinical research in rats.
  • To demonstrate the feasibility of integrating a stimulator, receiver coil, and microelectrode array into a compact LCP package.
  • To validate the system's efficacy in treating neuropathic pain in an animal model.

Main Methods:

  • Fabrication of a dome-shaped LCP package (13 mm diameter, 5 mm height) housing the stimulator circuit, receiver coil, and an 8-channel microelectrode array.
  • Utilizing wireless powering and control via an inductive link for untethered animal movement.
  • Monolithic encapsulation of the multilayered LCP substrate using a specialized spot-welding process.
  • In vivo validation using a neuropathic pain model in rats.

Main Results:

  • Successful development of a miniaturized, fully implantable, and battery-free DBS device.
  • Demonstrated wireless powering and control, enabling free behavior of untethered rats.
  • Significant increase in the mechanical withdrawal threshold in rats treated with the DBS system, indicating pain reduction.

Conclusions:

  • The developed LCP-based miniaturized DBS system is effective for preclinical research.
  • The battery-free, wireless design significantly enhances animal freedom and reduces invasiveness.
  • This technology shows promise for treating neuropathic pain and other neurological conditions through targeted brain stimulation.