Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

9.2K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.2K
Overview of DNA Repair02:25

Overview of DNA Repair

31.1K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
31.1K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

3.5K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.5K
Mutations01:35

Mutations

37.9K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
37.9K
DNA Damage Can Stall the Cell Cycle02:37

DNA Damage Can Stall the Cell Cycle

2.6K
2.6K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

12.6K
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
12.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-modal Features Analysis and Performance Assessment for Endovascular Surgery Skills.

Annals of biomedical engineering·2026
Same author

Do robot-assisted percutaneous vascular interventions improve effectiveness and safety compared with manual procedures: protocol for a systematic review and meta-analysis.

Systematic reviews·2026
Same author

Paraventricular oxytocin neurons attenuate post-ischemic brain injury by suppressing microglia-mediated neuroinflammation.

Cell communication and signaling : CCS·2026
Same author

A novel nutritional index for predicting stroke-heart syndrome and clinical outcomes after endovascular treatment.

Frontiers in nutrition·2026
Same author

Preprocedural acute silent ischemic lesions and inhospital stroke after percutaneous transluminal angioplasty and stenting for severe symptomatic intracranial atherosclerotic stenosis.

Journal of neurointerventional surgery·2026
Same author

Association of the C-Reactive Protein-Triglyceride-Glucose Index with Stroke-Heart Syndrome and Clinical Prognosis in Patients Undergoing Endovascular Treatment.

Journal of cardiovascular development and disease·2026

Related Experiment Video

Updated: Jul 10, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

3.6K

DNA damage response, a double-edged sword for vascular aging.

Xiao Zhang1, Qing Zhao2, Tao Wang3

  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; China International Neuroscience Institute (China-INI), Beijing 100053, China.

Ageing Research Reviews
|November 25, 2023
PubMed
Summary

Vascular aging, a risk factor for cardiovascular disease, is influenced by DNA damage response (DDR) pathways. Both deficient and overactive DDR can accelerate vascular aging, highlighting a complex role for DDR in this process.

Keywords:
DNA damage responseDeficiencyOveractivationPotential therapyVascular aging

More Related Videos

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

1.5K
Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

10.3K

Related Experiment Videos

Last Updated: Jul 10, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

3.6K
Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

1.5K
Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

10.3K

Area of Science:

  • Gerontology
  • Cardiovascular Biology
  • Molecular Biology

Background:

  • Vascular aging is a primary risk factor for age-related cardiovascular diseases, contributing significantly to morbidity and mortality.
  • Key characteristics include increased vascular diameter, intima-medial thickening, chronic inflammation, calcification, arterial stiffening, and atherosclerosis.
  • DNA damage and its response pathways (DDR) are implicated as critical factors in vascular aging.

Purpose of the Study:

  • To review the multifaceted role of DNA damage response (DDR) pathways in the process of vascular aging.
  • To explore how both deficient and overactive DDR mechanisms contribute to vascular aging.
  • To identify potential therapeutic targets within DDR pathways for mitigating vascular aging.

Main Methods:

  • Literature review synthesizing evidence on DDR pathways and vascular aging.
  • Analysis of studies investigating the impact of DNA damage accumulation on vascular health.
  • Examination of research on specific DDR proteins (e.g., PARP, ATM) in the context of vascular aging.

Main Results:

  • Deficient DDR, leading to unrepaired DNA damage or mutations, can promote vascular aging.
  • Over-activation of certain DDR proteins, including PARP and ATM, can also accelerate vascular aging.
  • DDR exhibits a dual role, with both insufficient and excessive activity negatively impacting vascular health.

Conclusions:

  • DNA damage response pathways play a complex, dual role in vascular aging.
  • Further investigation is needed to fully elucidate the mechanisms of DDR in vascular aging.
  • Understanding DDR's role is crucial for developing novel therapeutic strategies against age-related cardiovascular diseases.