Related Experiment Video
Updated: Sep 18, 2026

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila
Published on: April 15, 2015
Comparison of the effects of atropine sulfate and ethanol on performance
Abstract:
The flight simulator performance decrements resulting from atropine injections were compared to similar decrements resulting from ethanol toxicosis. There were 20 volunteers that received 0.0, 0.5, 1.0, 2.0, and 4.0 X 75 kg-1 of atropine sulfate under double-blind conditions. The performance decrements at each atropine sulfate treatment level for each subject were determined by computing root mean square (RMS) deviations for five flight performance variables. The data set from a previous study concerned with the effects of ethanol on pilot performance was reanalyzed, and the decrements for the five variables at the 0.082% blood alcohol level (BAL) were computed. Probit analysis was used to estimate the effective dose (ED50) at which 50% of the subjects in the atropine sulfate experiment were expected to display decrements in excess of those observed for the 0.082% BAL. The ED50 was 3.12 mg of atropine sulfate.
More Related Videos
10:35An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans
Published on: April 9, 2015
07:50A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
Published on: January 29, 2017
Related Concept Videos
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Direct-Acting Cholinergic Agonists: Therapeutic Uses
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
CNS Depressants: Alcohol and Nicotine
Stages of General Anesthesia