A novel sophorolipids extraction method by yeast fermentation process for enhanced skin efficacy

Area of Science:

• Phytochemistry
• Biotechnology
• Dermatology

Background:

• Traditional Oriental herbs possess valuable phytochemicals and bioactivities.
• Bio conversion extraction technology offers a novel method for enhancing herbal properties.

Purpose of the Study:

• To identify phytochemicals in five Korean traditional medical herbs using bio conversion extraction.
• To evaluate the skin-related efficacies of the resulting Bioconversion Oji complex.

Main Methods:

• A two-step bio conversion process involving fermentation with Candida bombicola and subsequent fermentation with five natural plants.
• In vitro studies on HaCaT cells assessed viability and mRNA expression related to skin anti-inflammation, moisturizing, and barrier improvement.
• In vivo studies on 21 participants evaluated anti-inflammatory, moisturizing, and skin barrier effects over 4 weeks.

Main Results:

• Bio conversion significantly increased amino acid and lipid content, with 23 flavonoids identified.
• Bioconversion Oji complex was non-toxic and demonstrated significant anti-inflammatory, moisturizing, and skin barrier improvements in both in vitro and clinical studies.

Conclusions:

• Bioconversion Oji complex exhibits skin-friendly properties with notable anti-inflammatory, hydrating, and barrier-enhancing effects.
• The study supports the use of Bioconversion Oji complex as an active ingredient in cosmetic and skincare products.