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Abnormal brain structure in atopic dermatitis: Evidence from Mendelian randomization study.
Yue Chen1, Liqian Cui2, Hao Li3
1Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, Guangdong, China.
Summary
Atopic dermatitis (AD) is causally linked to reduced brain structure, including caudate nucleus volume and cortical thickness. This Mendelian randomization study suggests AD may impact brain regions associated with cognition and mood.
Area of Science:
- Neuroscience
- Genetics
- Dermatology
Background:
- Structural brain abnormalities are observed in atopic dermatitis (AD) patients, but the causal factors remain unclear.
- Mendelian randomization (MR) is employed to investigate the potential causal effect of AD on brain structure.
Conclusions:
- Decreased caudate nucleus, posterior cingulate cortex, isthmus cingulate cortex, and supramarginal gyrus are suggestively associated with higher AD risk.
- Further research into these brain regions is recommended to elucidate mechanisms and develop novel AD therapies.
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