Functional, transcriptomic, and lipidomic studies of the choC gene encoding a phospholipid methyltransferase in Aspergillus fumigatus
Jiao Pan1, Xinyu Yang2, Cuiting Hu2
1Institute for Cultural Heritage and History of Science and Technology, University of Science and Technology Beijing , Beijing, China.
Microbiology Spectrum
|November 27, 2023
Abstract
Importance:
This study explored the phospholipid metabolic pathway in A. fumigatus and its relationship with fungal growth, metabolism, and pathogenicity. ChoC, based on its critical roles in many aspects of the fungus and relatively conserved characteristics in filamentous fungi with low similarity with mammalian ones, can be a novel target of new antifungal drugs.
