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Patient-Derived Microphysiological Systems for Precision Medicine.

Jihoon Ko1, Jiyoung Song2, Nakwon Choi2,3,4

  • 1Department of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do, 13120, Republic of Korea.

Advanced Healthcare Materials
|November 27, 2023
PubMed
Summary
This summary is machine-generated.

Patient-derived microphysiological systems (P-MPS) offer insights into individual patient traits for precision medicine. These systems integrate patient samples into microfluidic devices for better treatment strategies.

Keywords:
microphysiological systempatient-derivedphysiologically-relevantprecision medicine

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Area of Science:

  • Biomedical Engineering
  • Translational Medicine
  • Regenerative Medicine

Background:

  • Patient-derived microphysiological systems (P-MPS) are crucial for advancing precision medicine.
  • They integrate patient-derived cells, organoids, and stem cells into microphysiological systems (MPS).
  • P-MPS bridge the gap between traditional in vitro models and clinical outcomes.

Purpose of the Study:

  • To review the development and significance of P-MPS in precision medicine.
  • To provide guidance on engineering approaches for P-MPS development.
  • To explore the clinical implications and outcomes derived from P-MPS.

Main Methods:

  • Integration of patient-derived samples (cells, organoids, iPSCs) into MPS.
  • Development of microfluidic devices for P-MPS.
  • Application of high-content analysis for P-MPS experimentation.

Main Results:

  • P-MPS enable high biological relevance and high-throughput experimentation.
  • Physiologically relevant data obtained from diverse patient-derived samples.
  • Demonstrated clinical relevance and insights into individual patient characteristics.

Conclusions:

  • P-MPS are vital tools for understanding individual patient characteristics.
  • They facilitate the development of personalized treatment strategies.
  • P-MPS represent a significant advancement in nonclinical assessment for clinical applications.