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Cerebral border zone infarctions: An etiologic study
Mazyar Hashemilar1,2, Parla Tohidi1,2, Nasrin Forghani1,2
1Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Current Journal of Neurology
|November 27, 2023
Summary
Large artery atherosclerosis is a common cause of internal and external cerebral border zone infarctions (BZIs). Cardioembolism is more prevalent in external BZIs, suggesting different etiologies for these stroke subtypes.
Area of Science:
- Neurology
- Vascular Neurology
- Stroke Medicine
Background:
- Cerebral border zone infarctions (BZIs) occur at arterial territory junctions.
- Internal and external BZIs are distinguished by MRI patterns.
- Etiology and pathophysiology of BZI subtypes remain debated.
Purpose of the Study:
- To investigate etiologic differences between internal and external BZIs.
- To inform tailored treatment strategies for BZI patients.
Main Methods:
- Prospective study of 106 acute ischemic stroke patients with BZIs (2017-2019).
- Etiologies classified using the Trial of Org 10172 in Acute Stroke Treatment (TOAST) system.
- Analysis of clinical, laboratory, and hemodynamic factors.
Main Results:
- Large artery atherosclerosis (LAA) was the most frequent etiology for both internal and external BZIs.
- LAA was significantly more common in internal BZIs (P=0.016).
- Cardioembolism was a more frequent etiology in external BZIs (P=0.046).
Conclusions:
- LAA is a primary cause for both internal and external cerebral BZIs.
- Cardioembolism plays a more significant role in the etiology of external BZIs.
