Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

255
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
255
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

181
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
181
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

190
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
190
Disorders of the Female Reproductive System01:24

Disorders of the Female Reproductive System

368
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
368
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

232
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
232

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inpatient pharmacist impact on guideline directed medical therapy in heart failure with reduced ejection fraction.

Journal of the American Pharmacists Association : JAPhA·2026
Same author

Antimicrobial Pharmacokinetic and Pharmacodynamic Considerations in Special Populations: A Call to Action.

Open forum infectious diseases·2026
Same author

Creation and application of a value-based framework for formulary management.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same author

Postoperative outcomes based on timing of definitive fixation and flap coverage in Gustilo-Anderson 3B open tibia fractures.

Injury·2026
Same author

Automated tagging of intraoperative physiologic events: understanding the clinical consequences.

Surgical endoscopy·2025
Same author

Tumor control following gamma knife radiosurgery for parasagittal meningiomas: a single institution retrospective analysis.

Clinical neurology and neurosurgery·2025
Same journal

The CALLY Index as a Predictive Tool for Surgical Site Infection After Pancreaticoduodenectomy: A Retrospective Cohort Study.

Surgical infections·2026
Same journal

Preoperative Prediction of Acute Appendicitis Pathological Type and Complicating Perforation Using IL-6 and IL-10.

Surgical infections·2026
Same journal

Outcomes and Predictors of Fungal Necrotizing Soft Tissue Infections.

Surgical infections·2026
Same journal

Light at the End of the Tunnel! Effects of 405 nm Visible Light Disinfection on Surgical Site Infection: A Prospective Randomized Cohort Study.

Surgical infections·2026
Same journal

Guideline-Directed Administration of Prophylactic Antibiotic-Loaded Bone Cement in Total Knee Arthroplasty Does Not Lower Infection Rate.

Surgical infections·2026
Same journal

Highlights from the 38th Annual Meeting of the Japanese Society of Surgical Infection.

Surgical infections·2026
See all related articles

Related Experiment Video

Updated: Jul 9, 2025

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

5.4K

Identification of Risk Factors for Intra-Abdominal Candidiasis.

Kelsey Habighorst1, James M Sanders1,2, Sara A Hennessy3

  • 1Department of Pharmacy, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Surgical Infections
|November 27, 2023
PubMed
Summary
This summary is machine-generated.

Identifying patients at high risk for intra-abdominal candidiasis (IAC) is crucial. Corticosteroid exposure, upper gastrointestinal surgery, and mechanical ventilation are key risk factors for developing this serious infection.

Keywords:
Candida spp.intra-abdominal infectionsinvasive Candidiasisrisk factors

More Related Videos

Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection
06:28

Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection

Published on: November 27, 2014

10.2K
A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

14.8K

Related Experiment Videos

Last Updated: Jul 9, 2025

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

5.4K
Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection
06:28

Modeling Mucosal Candidiasis in Larval Zebrafish by Swimbladder Injection

Published on: November 27, 2014

10.2K
A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

14.8K

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Surgical Infections

Background:

  • Intra-abdominal candidiasis (IAC) presents significant challenges in hospitalized patients, contributing to high morbidity and mortality rates.
  • Early identification of high-risk individuals is essential for targeted antifungal therapy, potentially reducing adverse effects from unnecessary treatments in low-risk patients.

Purpose of the Study:

  • To identify independent risk factors associated with the development of microbiologically confirmed intra-abdominal candidiasis (IAC).
  • To aid in the early detection of patients who may benefit from prompt antifungal treatment.

Main Methods:

  • A retrospective, case-control study involving patients over 18 with confirmed intra-abdominal infections.
  • Inclusion criteria focused on gastrointestinal cultures positive for Candida spp. (cases) or bacterial isolates (controls) obtained intra-operatively or via drain within 24 hours.
  • Multivariable regression analysis was employed to determine independent risk factors for IAC, excluding patients on peritoneal dialysis.

Main Results:

  • Multivariable analysis revealed significant associations between IAC and exposure to corticosteroids (OR, 5.79), upper gastrointestinal tract surgery (OR, 3.51), and mechanical ventilation (OR, 3.09).
  • The predictive model demonstrated an area under the receiver operating characteristic (AUROC) of 0.7813.
  • Statistical significance was observed for all identified risk factors (p < 0.0001 for corticosteroids, p = 0.017 for surgery, p = 0.002 for ventilation).

Conclusions:

  • Exposure to corticosteroids, undergoing upper gastrointestinal tract surgery, and requiring mechanical ventilation are independently associated with an increased risk of developing confirmed IAC.
  • These identified factors can assist clinicians in stratifying patients and making informed decisions regarding the necessity of antifungal therapy.