Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The deubiquitinase USP17 regulates the expression and activity of the oncogenic driver β-catenin in colorectal cancer.

Oncogene·2026
Same author

Architecture of the neutrophil compartment.

Nature·2025
Same author

Oncogenic driver mutations underlie the spatial tumour immune landscape of non-small cell lung cancer.

Nature communications·2025
Same author

A spatial map of MAPK-activated immunosuppressive myeloid populations in pediatric low-grade glioma.

Nature immunology·2025
Same author

Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer.

Nature immunology·2025
Same author

A Dock8-dependent mechanosensitive central actin pool maintains T cell shape and protects the nucleus during migration.

Science immunology·2025
Same journal

Editorial Expression of Concern: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.

Nature immunology·2026
Same journal

Inflammatory immune modulators of AML lung infiltration and respiratory failure.

Nature immunology·2026
Same journal

The neuroimmune system and cognition.

Nature immunology·2026
Same journal

Critical connections.

Nature immunology·2026
Same journal

Innate immune signaling and functions in astrocytes.

Nature immunology·2026
Same journal

Epigenetic mechanisms of inflammatory memory in the central nervous system.

Nature immunology·2026
See all related articles

Related Experiment Video

Updated: Jul 9, 2025

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.2K

Decoding the tumor microenvironment with spatial technologies.

Logan A Walsh1,2, Daniela F Quail3,4,5

  • 1Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec, Canada. logan.walsh@mcgill.ca.

Nature Immunology
|November 27, 2023
PubMed
Summary
This summary is machine-generated.

Visualizing the tumor microenvironment (TME) reveals cellular heterogeneity and spatial architecture crucial for understanding cancer progression and immunotherapy response. Emerging spatial technologies, integrated with AI and multiomics, offer a holistic view of the TME.

More Related Videos

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K
Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

7.3K

Related Experiment Videos

Last Updated: Jul 9, 2025

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

17.2K
Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.9K
Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

7.3K

Area of Science:

  • Oncology
  • Immunology
  • Bioinformatics

Background:

  • Understanding tumor microenvironment (TME) cellular heterogeneity and spatial organization is vital for predicting disease progression and therapeutic outcomes, especially in cancer immunotherapy.
  • Immune cell positioning within the tumor landscape significantly impacts treatment efficacy.
  • Single-cell technologies are evolving towards spatial dimension integration for comprehensive TME analysis.

Purpose of the Study:

  • To review emerging spatial technologies for TME visualization.
  • To highlight their applications in tumor immunology.
  • To discuss future opportunities with artificial intelligence (AI) and multiomics data integration.

Main Methods:

  • Assessment of strengths and limitations of current spatial technologies.
  • Focus on applications in tumor immunology.
  • Exploration of AI and multiomics integration for TME analysis.

Main Results:

  • Spatial technologies offer enhanced visualization of cellular heterogeneity and architecture within the TME.
  • These technologies are crucial for understanding immune cell interactions and their impact on immunotherapy efficacy.
  • Integration with AI and multiomics promises a more comprehensive understanding of the TME.

Conclusions:

  • Emerging spatial technologies are revolutionizing TME research.
  • Combining spatial data with AI and multiomics is key to a holistic TME picture.
  • This integrated approach will advance cancer progression and immunotherapy response understanding.