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Related Experiment Video

Updated: Jul 9, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Placental accelerated aging in antenatal depression.

Haleema Saeed¹, Jing Wu², Markos Tesfaye³

¹National Human Genome Research Institute, National Institutes of Health, Bethesda, MD (Dr Saeed); Department of Maternal-Fetal Medicine, Medstar Washington Hospital Center, Washington, DC (Drs Saeed).

American Journal of Obstetrics & Gynecology MFM

|November 28, 2023

Summary

Antenatal depressive symptoms, particularly in the second trimester, are linked to accelerated placental aging. This finding suggests a potential mechanism connecting maternal depression to adverse pregnancy outcomes via placental dysfunction.

Keywords:

DNA methylation epigenetic clock fetal sex maternal mental health pregnancy premature senescence prenatal screening second trimester

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Published on: November 20, 2015

Area of Science:

Reproductive Biology
Developmental Biology
Epigenetics

Background:

Antenatal maternal depression is linked to adverse pregnancy outcomes and long-term child development issues.
Previous research indicates a connection between antenatal depression, placental DNA methylation, and placental epigenetic aging.
Placental aging has been associated with poor pregnancy outcomes like preterm birth and preeclampsia.

Purpose of the Study:

To investigate the association between antenatal depressive symptoms and placental epigenetic age acceleration.
To determine if placental epigenetic aging mediates the relationship between antenatal depression and poor pregnancy outcomes.

Main Methods:

The study analyzed placenta samples from 301 women in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies - Singletons.
Maternal depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale across three trimesters.
Placental epigenetic age acceleration was calculated using DNA methylation data and a validated epigenetic clock.

Main Results:

Women with depressive symptoms in the second trimester showed higher placental age acceleration (0.41 weeks).
Sustained depressive symptoms in the first and second trimesters were significantly associated with increased placental age acceleration (0.72 weeks).
The association was stronger in pregnancies with male fetuses.

Conclusions:

Second-trimester antenatal depressive symptoms are associated with accelerated placental aging.
Accelerated placental aging may be a key mechanism linking maternal depression to pregnancy complications.
Further research is needed to explore the implications for placental dysfunction and offspring outcomes.