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Myocarditis following Coronavirus vaccination.
Khouloud Ferchichi1,2, Imen Aouinti1,2, Ahmed Zaiem1,2
1National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue Dr Zouheïr Essafi, Tunis 1006, Tunisia.
Clinical Immunology Communications
|November 28, 2023
Summary
Myocarditis cases following COVID-19 vaccination are rare and mild in Tunisia. All reported patients recovered quickly without severe complications, indicating a favorable outcome post-vaccination.
Area of Science:
- Cardiology
- Vaccinology
- Public Health
Background:
- Myocarditis has been identified as a rare adverse reaction to SARS-CoV-2 mRNA vaccines.
- This adverse reaction is not consistently documented across all vaccine types for COVID-19.
Purpose of the Study:
- To report and analyze cases of myocarditis following COVID-19 vaccination in Tunisia.
- To assess the characteristics and outcomes of these myocarditis cases.
Main Methods:
- Case series reporting myocarditis cases submitted to the Tunisian national pharmacovigilance center.
- Diagnosis confirmed using Brighton's case definition for myocarditis.
- Vaccine causality assessed via the updated French imputability method (Bégaud et al.).
Main Results:
- Five cases of myocarditis post-COVID-19 vaccination were analyzed.
- Patients were predominantly male (M/F ratio 4:1) with a mean age of 30 years.
- Common symptoms included chest pain and dyspnea; cardiac MRI confirmed diagnosis in most cases. All patients recovered within days without requiring intensive care.
Conclusions:
- Myocarditis cases associated with COVID-19 vaccination in the Tunisian population are infrequent.
- These cases are generally not severe and exhibit a rapid, positive clinical outcome.
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