The bidirectional effects between cognitive ability and brain morphology: A life course Mendelian randomization
Roxanna Korologou-Linden1,2, Isabel K Schuurmans3,4, Charlotte A M Cecil3,4,5,6
1Medical Research Council Integrative Epidemiology Unit, University of Bristol, BS8 2BN, United Kingdom.
Medrxiv : the Preprint Server for Health Sciences
|November 28, 2023
Summary
Cognitive ability and brain morphology show bidirectional effects throughout life. Early childhood and adulthood reveal the earliest influences, highlighting childhood as a critical period for interventions.
Area of Science:
- Neuroscience
- Human Development
- Genetics
Background:
- The relationship between brain structure and cognitive function across the lifespan is not well understood.
- Previous studies often focused on general brain measurements, neglecting regional variations.
Conclusions:
- Cognitive ability influences brain morphology consistently across the lifespan.
- Childhood emerges as a potentially crucial period for interventions targeting brain development and cognitive function.
Keywords:
ABCDALSPACCognitive abilityGeneration RIMAGENMendelian randomizationUK Biobankbrain reservebrain structurelifecourseMore Related Videos
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