Pathophysiological Hypothesis of COVID-19 Psychosis

Area of Science:

• Neuroscience
• Infectious Diseases
• Psychiatry

Background:

• The emergence of SARS-CoV-2 in late 2019 has been linked to diverse clinical manifestations beyond respiratory illness.
• Neuropsychiatric symptoms, including psychosis, are increasingly reported in patients with SARS-CoV-2 infection or post-resolution.

Approach:

• This narrative review synthesizes current understanding of the potential link between SARS-CoV-2 and psychosis.
• It examines the neurotropic capabilities of the virus and the underlying neurobiological mechanisms of psychosis.

Key Points:

• SARS-CoV-2 exhibits neurotropic potential, suggesting direct or indirect effects on the central nervous system.
• Psychotic episodes can occur during acute infection or in the aftermath of SARS-CoV-2 illness.
• Understanding the neurobiology of these manifestations is crucial for patient management.

Conclusions:

• A potential association exists between SARS-CoV-2 infection and the onset of psychosis.
• Further research into viral neurotropism and psychosis neurobiology is warranted to elucidate this relationship.