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68 Ga-PSMA Uptake in Solar Elastosis.
Merve Nida Calderon Tobar1, Hasan Önner1, Cahit Yavuz2
1From the Departments of Nuclear Medicine.
Clinical Nuclear Medicine
|November 28, 2023
Summary
A Gallium-68 prostate specific membrane antigen (PSMA) PET/CT scan for prostate cancer staging showed increased uptake in solar elastosis, a sun-induced skin condition. This highlights another case of benign skin findings with elevated 68 Ga-PSMA uptake.
Area of Science:
- Nuclear medicine imaging
- Dermatology
- Oncology
Background:
- Prostate-specific membrane antigen (PSMA) is a validated target for prostate cancer imaging.
- 68 Ga-PSMA PET/CT is widely used for prostate cancer staging and recurrence detection.
- Increased 68 Ga-PSMA uptake has been observed in various non-prostate cancer lesions, including some cutaneous conditions.
Purpose of the Study:
- To report a case of increased 68 Ga-PSMA uptake in solar elastosis during prostate cancer staging.
- To contribute to the understanding of benign conditions that may exhibit PSMA avidity.
Main Methods:
- A patient with prostate cancer underwent 68 Ga-PSMA PET/CT for staging.
- Imaging findings of increased tracer uptake in solar elastosis were noted and analyzed.
Main Results:
- The 68 Ga-PSMA PET/CT scan revealed unexpected increased radiotracer uptake in areas of solar elastosis.
- Solar elastosis, a degenerative skin condition, demonstrated PSMA avidity in this patient.
Conclusions:
- This case adds to the literature demonstrating that solar elastosis can exhibit increased 68 Ga-PSMA uptake.
- Clinicians should be aware of potential benign cutaneous uptake of 68 Ga-PSMA, which may be mistaken for metastatic disease.
