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Colloidal precipitates

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

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On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

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Efficient Construction of pH-Stimuli-Responsive Colloidosomes with High Encapsulation Efficiency.

Jia Jia^1,2, Rong-Kun Liu^1,2, Qian Sun³

¹State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, PR China.

Langmuir : the ACS Journal of Surfaces and Colloids

|November 28, 2023

Summary

High-gravity technology enables efficient, pH-responsive colloidosome construction for drug delivery. This method improves encapsulation efficiency and controlled release of anticancer drugs like doxorubicin.

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Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Colloidosomes show promise for drug delivery, enhancing efficacy and reducing side effects.
Current limitations include low encapsulation efficiency and complex preparation methods.

Purpose of the Study:

To develop an efficient method for creating pH-stimuli-responsive colloidosomes.
To achieve high encapsulation efficiency for drug delivery applications.

Main Methods:

Utilized high-gravity technology for rapid emulsion preparation and enhanced micromixing.
Explored self-assembly of latex particles with varying methacrylic acid content.
Encapsulated the anticancer drug doxorubicin within the synthesized colloidosomes.

Main Results:

Achieved regular spherical colloidosomes with a mean diameter of 2.82 μm.
Realized a high encapsulation efficiency of 76.5% for doxorubicin.
Demonstrated pH-stimuli-responsive drug release following a first-order sustained release model.

Conclusions:

High-gravity technology offers an efficient route for constructing intelligent responsive colloidosomes.
These colloidosomes serve as effective drug carriers with controlled release capabilities.
This approach advances the development of advanced drug delivery systems for biomedical applications.