The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations

Area of Science:

• Molecular Biology
• Cancer Research
• Genetics

Background:

• Alternative splicing (AS) is frequently dysregulated in various cancers.
• Splicing processes are critically dependent on splicing factors.
• Long noncoding RNAs (lncRNAs) are emerging regulators of AS through interactions with splicing factors.

Purpose of the Study:

• To review the mechanisms by which lncRNAs regulate AS via splicing factors.
• To explore the role of AS, splicing factors, and lncRNAs in cancer development and progression.
• To discuss therapeutic strategies targeting these components in cancer.

Main Methods:

• Literature review focusing on lncRNA-splicing factor interactions.
• Analysis of the role of aberrant splicing in oncogenesis.
• Examination of current therapeutic approaches targeting AS and related factors.

Main Results:

• lncRNAs modulate AS by directly or indirectly interacting with splicing factors.
• Mis-regulation of splicing factors and lncRNAs contributes to cancer development.
• Aberrant splicing, splicing factors, and lncRNAs represent promising therapeutic targets.

Conclusions:

• Understanding the interplay between lncRNAs, AS, and splicing factors is crucial for cancer therapy.
• Targeting these elements offers potential for novel cancer treatment strategies.
• Further research is needed to address current challenges and unanswered questions in the field.