Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Probability Laws01:49

Probability Laws

40.9K
Overview
40.9K
Epistasis Analysis01:09

Epistasis Analysis

5.0K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.0K
Genetic Lingo01:11

Genetic Lingo

102.9K
Overview
102.9K
Human Genetics01:28

Human Genetics

586
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
586
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.6K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.6K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

34.6K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a surface-enhanced Raman scattering-based immunochromatographic assay for sensitive detection of carbaryl residues.

Analytical methods : advancing methods and applications·2026
Same author

Partial submergence-induced adventitious root emergence in cucumber requires CsRBOHB-mediated ROS production.

Plant physiology·2026
Same author

Surveillance and analysis of adverse events following immunization (AEFI) with measles, mumps, and rubella (MMR) vaccine in Zhejiang Province, China, 2020-2025.

Frontiers in public health·2026
Same author

Ethylene-mediated CsWRKY41 regulates the PYL-PP2C module to promote adventitious root formation in cucumber under waterlogging stress.

Plant physiology·2026
Same author

Immunogenicity and safety of co-administered <i>Escherichia coli</i>-produced bivalent HPV-16/18 vaccine and hepatitis E vaccine.

Frontiers in immunology·2026
Same author

Population waning trajectories of vaccine-induced tetanus immunity in Zhejiang, China.

Frontiers in immunology·2026

Related Experiment Video

Updated: Jul 9, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

849

Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study.

Yuhang Xing1, Zhen Wang1, Xiaohua Qi1

  • 1Department of Public Health Response, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.

Hypertension in Pregnancy
|November 29, 2023
PubMed
Summary

This study suggests COVID-19 increases pre-eclampsia/eclampsia risk. Mendelian randomization analysis revealed a significant genetic correlation, indicating a potential causal link between COVID-19 and adverse pregnancy outcomes.

Keywords:
COVID-19Mendelian randomizationseclampsiapre-eclampsia

More Related Videos

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.7K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K

Related Experiment Videos

Last Updated: Jul 9, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

849
Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

1.7K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.2K

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Genetics and Epidemiology

Background:

  • Pre-eclampsia/eclampsia poses significant risks to maternal and fetal health.
  • The potential impact of COVID-19 infection on pregnancy complications remains an area of active investigation.

Purpose of the Study:

  • To investigate a potential causal relationship between COVID-19 and the risk of developing pre-eclampsia/eclampsia.
  • To utilize Mendelian randomization (MR) design for robust causal inference.

Main Methods:

  • Two-sample Mendelian randomization analyses were conducted using genome-wide association study (GWAS) summary statistics.
  • Genetic correlation between COVID-19 susceptibility/hospitalization and pre-eclampsia/eclampsia was estimated.
  • Inverse variance weighting, weighted median, and MR-Egger methods were employed for primary and sensitivity analyses.

Main Results:

  • A significant positive genetic correlation was found between COVID-19 susceptibility and pre-eclampsia/eclampsia (OR = 1.23).
  • COVID-19 hospitalization was significantly associated with an increased risk of pre-eclampsia/eclampsia (OR = 1.15).
  • Results remained robust across sensitivity analyses, supporting the primary findings.

Conclusions:

  • Findings suggest a potential causal link where COVID-19 infection may elevate the risk of pre-eclampsia/eclampsia.
  • These results highlight the importance of considering COVID-19's impact on pregnancy outcomes in clinical practice.
  • Future research should focus on preventive and therapeutic strategies to mitigate these complications.