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THE CONNECTION BETWEEN BILE ACIDS AND TYPE 2 DIABETES MELLITUS - A REVIEW
Luis Jesuino de Oliveira Andrade1, Gabriela Correia Matos de Oliveira2, Luis Matos de Oliveira3
1Universidade Estadual de Santa Cruz, Departamento de Saúde, Ilhéus, BA, Brasil.
Arquivos De Gastroenterologia
|November 29, 2023
Summary
Bile acids (BAs) play a key role in type 2 diabetes mellitus (DM2) by regulating metabolism. Targeting BAs offers a promising new therapeutic strategy for managing DM2 and its complications.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Cholesterol Metabolism
Background:
- Bile acids (BAs) are liver-synthesized cholesterol metabolites involved in metabolic syndrome and type 2 diabetes mellitus (DM2).
- DM2 is a chronic condition marked by insulin resistance, pancreatic beta-cell dysfunction, and hyperglycemia, leading to severe complications.
Conclusions:
- Bile acids (BAs) are integral to DM2 pathogenesis through their influence on critical metabolic pathways.
- Targeting bile acids (BAs) presents an innovative therapeutic avenue for type 2 diabetes mellitus (DM2) management.
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