Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

860
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
860
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

71
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
71
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

1.1K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.1K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

501
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
501
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between the mean diameter of the thyroid lobes and the transverse diameter of the trachea: an ultrasound marker for goiters.

Radiologia brasileira·2025
Same author

Intranasal insulin in Alzheimer disease (diabetes <i>in situ</i>?): a systematic review and meta-analysis.

Dementia & neuropsychologia·2025
Same author

Decoding the relationship between cow's milk proteins and development of type 1 diabetes mellitus.

Archives of endocrinology and metabolism·2024
Same author

Brain insulin resistance and Alzheimer's disease: a systematic review.

Dementia & neuropsychologia·2024
Same author

THE CONNECTION BETWEEN BILE ACIDS AND TYPE 2 DIABETES MELLITUS - A REVIEW.

Arquivos de gastroenterologia·2023
Same author

ASSOCIATION BETWEEN NONALCOHOLIC FATTY PANCREATIC DISEASE AND TRIGLYCERIDE/GLUCOSE INDEX.

Arquivos de gastroenterologia·2023

Related Experiment Video

Updated: Jun 3, 2025

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
10:17

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

7.0K

ASSOCIATION OF "METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC PANCREAS DISEASE" (MASPD) AND INSULIN RESISTANCE.

Luís Jesuino de Oliveira Andrade1, Gabriela Correia Matos de Oliveira2, Alcina Maria Vinhaes Bittencourt3

  • 1Departamento de Saúde, Universidade Estadual de Santa Cruz, Ilhéus, BA, Brasil.

Arquivos De Gastroenterologia
|January 8, 2025
PubMed
Summary

Metabolic dysfunction-associated steatotic pancreas disease (MASPD) is significantly linked to insulin resistance (IR). This finding highlights the pancreas's crucial role in metabolic health and the development of IR.

More Related Videos

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

67.9K
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

2.5K

Related Experiment Videos

Last Updated: Jun 3, 2025

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
10:17

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

7.0K
Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

67.9K
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

2.5K

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolic Diseases

Background:

  • Metabolic dysfunction-associated steatotic pancreas disease (MASPD) is an emerging condition.
  • The relationship between MASPD and insulin resistance (IR) requires further investigation.

Purpose of the Study:

  • To investigate the association between MASPD and IR.

Main Methods:

  • A cross-sectional study of 157 participants with MASPD.
  • Serum glucose, insulin, lipid profiles, and glycated hemoglobin were measured.
  • Logistic regression analysis was used to assess the association between MASPD and IR markers.

Main Results:

  • MASPD was significantly correlated with markers of IR, including the TyG index and HOMA-IR.
  • Adjusted odds ratios indicated a strong association between MASPD and IR.
  • P-values were <0.05, indicating statistical significance.

Conclusions:

  • MASPD is significantly associated with markers of insulin resistance.
  • These findings suggest MASPD may contribute to the development of IR.
  • Maintaining pancreatic health is important for managing metabolic disorders.