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Carsten Faber1, Peter Skov Jensen2, Ann Sofia Skou Thomsen1

  • 1Afdeling for Øjensygdomme, Københavns Universitetshospital - Rigshospitalet.

Ugeskrift for Laeger
|November 29, 2023
PubMed
Summary
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Ocular tumors are diverse with vague symptoms, some leading to high mortality. Early diagnosis, treatment, and personalized follow-up using tumor mutations improve survival rates for eye cancers.

Area of Science:

  • Ophthalmology
  • Oncology
  • Genetics

Background:

  • Ocular tumors represent a heterogeneous group of diseases originating from various eye tissues, often presenting with non-specific symptoms.
  • Certain ocular tumors are associated with high mortality rates, with a less than 50% survival rate beyond ten years.
  • The critical need for early diagnosis and prompt treatment in managing ocular malignancies is underscored by their potential for severe outcomes.

Approach:

  • This review examines the impact of centralization on patient outcomes in Denmark, noting decreased morbidity and increased survival rates.
  • The potential of utilizing tumor-specific somatic mutations for developing personalized follow-up strategies is explored.
  • The review discusses how insights from genetic mutations could pave the way for novel therapeutic approaches in ocular oncology.

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Key Points:

  • Ocular tumors present a diagnostic challenge due to their heterogeneity and unspecific symptoms.
  • High mortality rates are associated with certain types of ocular tumors, emphasizing the urgency of intervention.
  • Centralization of care and personalized medicine approaches show promise in improving patient survival and reducing disease burden.

Conclusions:

  • Early detection and intervention are paramount for improving outcomes in patients with ocular tumors.
  • Tumor-specific somatic mutations offer a promising avenue for personalized patient management and the development of targeted therapies.
  • The review advocates for the integration of genetic profiling into the clinical management of ocular tumors to enhance treatment efficacy and patient prognosis.