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Updated: Jul 9, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Rapid and General Access to α-Haloketones Using Quaternary Ammonium Salts as Halogen Sources

Nan Wu1, Mengfei Jiang1, Ashley Cao1

  • 1Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.

The Journal of Organic Chemistry
|November 29, 2023
PubMed
Summary

A new, scalable method efficiently prepares alpha-halogenated ketones using N-alkenoxypyridinium salts. This approach offers mild conditions and broad functional group compatibility for organic synthesis.

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