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Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Copper-Catalyzed Triyne Cyclization via Vinyl Cations
Chen Luo1, Yan-Xin Zheng1, Sheng-Biao Ji1
1Key Laboratory of Chemical Biology of Fujian Province and State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Abstract:
Herein, we describe an efficient copper-catalyzed cyclization of triynes via vinyl cation intermediates. The reaction leads to the practical and atom-economical synthesis of valuable polycyclic pyrroles by constructing three new rings in one step under mild reaction conditions. The proposed reaction mechanism shows the ordered and regioselective reaction of alkynes. Moreover, the possibility of such an asymmetric triyne cyclization also emerges.
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