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Blood-derived product therapies for SARS-CoV-2 infection and long COVID

Junzheng Wu1, Huichuan Yang2, Ding Yu1,3

  • 1Chengdu Rongsheng Pharmaceuticals Co., Ltd. Chengdu China.

Medcomm
|November 29, 2023
PubMed

Insights

Blood-derived products offer therapeutic strategies against COVID-19 and long COVID. Both virus-targeting and non-targeting options show promise for managing acute infection and long-term health issues.

Area of Science:

  • Immunology
  • Virology
  • Hematology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic, leading to significant global public health challenges.
  • Long COVID, a persistent health issue following acute infection, further exacerbates the impact of SARS-CoV-2.
  • Blood-derived products are being explored as critical therapeutic interventions for both acute COVID-19 and long COVID.

Purpose of the Study:

  • To review the advancements in blood-derived product therapies for COVID-19.
  • To discuss the effective application methods and clinical scenarios for these therapies.
  • To provide guidance for the rational use of blood products in managing COVID-19 and long COVID.

Main Methods:

  • Review of existing literature and clinical evidence on blood-derived product therapies for COVID-19.
  • Categorization of products into SARS-CoV-2-targeting and non-targeting groups.
  • Analysis of therapeutic properties, including antiviral, anti-inflammatory, immunomodulatory, antioxidant, and anticoagulatory effects.

Main Results:

  • SARS-CoV-2-targeting products (convalescent plasma, hyperimmune globulin, recombinant IgG) offer short-term viral control.
  • Non-SARS-CoV-2-targeting products (intravenous immunoglobulin, albumin) possess beneficial anti-inflammatory and supportive properties.
  • Evidence supports the rational application of these products for managing COVID-19 and long COVID symptoms.

Conclusions:

  • Blood-derived products represent a vital therapeutic avenue for combating COVID-19 and its long-term sequelae.
  • Strategic utilization of both targeted and non-targeted blood products can optimize patient outcomes.
  • Further clinical guidance is needed to refine the application of these therapies in diverse patient populations.

Keywords:
SARS‐CoV‐2 infectionanti‐inflammatoryblood‐derived productsimmunomodulatorylong COVIDpassive immunotherapy

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