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Published on: July 24, 2013
Bidirectional Relationship Between Circadian Rhythm and Frailty
Yu Pan1, Zhu Qing Feng1, Yan Yuan1
1Department of Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People's Republic of China.
Abstract:
Coupled with the ageing population, frailty, characterized by high prevalence and difficult treatment, has progressively evolved into a significant public health concern. Frail individuals can often observe serious metabolic disorders and sleep-wake cycle disruption, which may be caused by the decline in physiological reserve and increased vulnerability. Moreover, sleep-wake cycle disruptions and metabolic dysfunctions associated with circadian rhythm disorders are considered to be a central part of the disorder. Previous studies have documented a correlation between frailty and sleep-wake disruptions; nevertheless, the association between circadian rhythm disorders and frailty has not yet been definitively established. Hence, we hypothesize a bidirectional link between circadian rhythm disorders and frailty, with each condition exerting a significant influence on the progression of the other's disease trajectory.
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