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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study
Yu Pan1, Yan Yuan1, Juan Yang2
1Department of Geriatrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Non-high-density lipoprotein-cholesterol (non-HDL-C) shows a U-shaped link with frailty in older adults. Optimal non-HDL-C levels may reduce frailty risk, while very low or high levels increase it.
Area of Science:
- Gerontology
- Cardiovascular Health
- Metabolic Research
Background:
- Lipid metabolism modulation is a potential therapeutic target for frailty.
- The specific relationship between non-high-density lipoprotein-cholesterol (non-HDL-C) and frailty is not well-established.
Purpose of the Study:
- To investigate the association between non-HDL-C and frailty in older adults.
- To explore potential nonlinear relationships and identify optimal non-HDL-C ranges for frailty risk.
Main Methods:
- Utilized data from NHANES and CHARLS studies.
- Developed a 40-item frailty index scale.
- Employed LASSO regression, logistic regression, and Light Gradient Boosting Machine (LightGBM) for variable selection and model development.
Main Results:
- A U-shaped nonlinear association between non-HDL-C and frailty was identified.
- Lower frailty risk was observed within a non-HDL-C range of 117.54–194.64 mg/dL.
- Increased frailty risk was associated with non-HDL-C levels of 47.99–63.87 mg/dL or 274.01–259.65 mg/dL.
Conclusions:
- An intricate nonlinear association between non-HDL-C and frailty in the elderly is suggested.
- Further rigorous studies are needed to confirm these findings and their clinical implications.
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