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Related Experiment Video

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Identifying the white matter pathways involved in multiple sclerosis-related tremor using diffusion tensor imaging.

Ahmed Bayoumi¹, Khader M Hasan², Jorge Patino¹

¹Department of Neurology, McGovern Medical School at UTHealth, Houston, TX, USA.

Multiple Sclerosis Journal - Experimental, Translational and Clinical

|November 29, 2023

Summary

Multiple Sclerosis (MS) tremor is linked to widespread white matter changes. Diffusion tensor imaging revealed significant alterations in pathways, correlating with tremor severity, suggesting sensory or cerebellar circuit involvement.

Keywords:

Multiple sclerosis diffusion imaging proprioception tractography tremor white matter pathways

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Last Updated: Jul 9, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Area of Science:

Neuroimaging
Neurology
Biomedical Engineering

Background:

Tremor affects up to 45% of patients with Multiple Sclerosis (PwMS).
Existing understanding of MS tremor is limited, often relying on insights from other neurological disorders.
This highlights a need to address the unique pathology of MS-related tremor.

Purpose of the Study:

To characterize the brain white matter (WM) correlates of MS-related tremor.
To utilize diffusion tensor imaging (DTI) for detailed WM analysis in PwMS with tremor.

Main Methods:

A prospective case-control study design was employed.
PwMS with tremor were assessed for tremor severity and underwent MRI with DTI.
Matched controls (PwMS without tremor) were included for comparison.

Main Results:

Significant white matter diffusivity changes were observed in the tremor group compared to controls.
Key affected pathways included the right inferior longitudinal fasciculus and left corticospinal tract.
Tremor severity correlated significantly with diffusivity changes in the left medial lemniscus and forceps minor.

Conclusions:

MS-related tremor is associated with widespread white matter diffusivity changes.
The severity of tremor correlates with alterations in commissural and sensory projection pathways.
Findings suggest a role for proprioception or the dentato-rubro-olivary circuit in MS tremor.