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Exercise and microbiome: From big data to therapy.

Danni Meng1,2, Songwei Ai1,2, Michail Spanos3

  • 1Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China.

Computational and Structural Biotechnology Journal
|November 29, 2023
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Summary
This summary is machine-generated.

Regular exercise significantly impacts the human microbiome, offering therapeutic potential for various diseases. Understanding exercise-induced microbiome changes can guide treatments for conditions like obesity and inflammatory diseases.

Keywords:
MicrobiomeMicrobiomicsPhysical exerciseTherapy

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Area of Science:

  • Microbiome research
  • Exercise physiology
  • Multi-omics technologies

Background:

  • The human microbiome is integral to overall health and disease.
  • Advancements in microbiomics have led to extensive databases for research.
  • Exercise is recognized for its health benefits and therapeutic potential.

Purpose of the Study:

  • To provide an overview of microbiomics development and databases.
  • To describe multi-omics technologies for microbiome analysis.
  • To synthesize research on exercise-induced microbiome modifications and their therapeutic implications.

Main Methods:

  • Literature review of microbiomics, multi-omics, and exercise science.
  • Synthesis of studies on exercise and the microbiome.
  • Analysis of disease-specific microbiome alterations.

Main Results:

  • Exercise demonstrably modifies the human microbiome composition and function.
  • Specific microbiome profiles are associated with various diseases.
  • Multi-omics approaches enhance the understanding of microbiome-host interactions.

Conclusions:

  • Exercise-modulated microbiomes hold therapeutic promise for intestinal, metabolic, cardiovascular, and immune diseases.
  • Further research into exercise and the microbiome can unlock novel treatment strategies.
  • Integrating multi-omics data is key to deciphering microbiome-host-exercise relationships.