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Published on: February 9, 2011
Brevundimonas spp. infection in immunocompromised children: Two case reports
Andreé Altamirano-Beltrán1, Christian Chiara-Chilet2, José W López3
1MD, Hospital Nacional Guillermo Almenara Irigoyen, Lima, 15001, Perú.
Introduction:
Brevundimonas spp. are rare and opportunistic pathogens which may cause infections in patients who are immunocompromised or have underlying disease.
Case Report:
Two cases with a microbiological diagnosis of Brevundimonas aurantiaca and Brevundimonas spp. are presented. Both occurred in immunocompromised patients with post-chemotherapy febrile neutropenia for B-type acute lymphoblastic leukemia and hepatoblastoma. Antibiogram findings showed resistance to quinolones, ceftazidime, and intermediate resistance to cefepime, being susceptible to carbapenems and aminoglycosides. The cases responded favorably to the administration of carbapenem.
Conclusions:
The identification of the species and antimicrobial susceptibility profile favor response to infection, denoting the importance of species identification and the performance of an antibiogram to determine the different susceptibility profiles described in the literature on this emerging pathogen.
Insights
Brevundimonas infections are rare in immunocompromised patients. Prompt species identification and antimicrobial susceptibility testing are crucial for effective treatment with carbapenems, leading to favorable outcomes.
Area of Science:
- Medical Microbiology
- Infectious Diseases
Background:
- Brevundimonas species are rare opportunistic pathogens.
- Infections typically occur in immunocompromised individuals with underlying conditions.
Observation:
- Two cases of Brevundimonas aurantiaca and Brevundimonas spp. infections are presented.
- Both patients were immunocompromised with post-chemotherapy febrile neutropenia (B-acute lymphoblastic leukemia and hepatoblastoma).
Findings:
- Antibiogram revealed resistance to quinolones and ceftazidime, with intermediate resistance to cefepime.
- Susceptibility was noted for carbapenems and aminoglycosides.
- Both cases showed favorable response to carbapenem treatment.
Implications:
- Accurate species identification and antimicrobial susceptibility testing are vital for guiding treatment.
- Understanding susceptibility profiles is key to managing this emerging pathogen effectively.
