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Variety of Clostridioides difficile Ribotypes in CDI Patients in Las Vegas, NV
Amber Consul1, Mohamad Mubder2, Samrawit Misiker1
1Department of Chemistry and Biochemistry, University of Nevada-Las Vegas, Las Vegas, NV 89154, USA.
Germs
|April 29, 2026
Summary
This study identified novel Clostridioides difficile ribotypes in Las Vegas, a tourist hub not under CDC surveillance. The hypervirulent strain 027 was most common, offering insights into local infection dynamics.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health Surveillance
Background:
- Clostridioides difficile infection (CDI) is a significant healthcare-associated infection.
- Las Vegas, a major tourist destination, is not currently monitored by the CDC for CDI prevalence.
- Understanding local CDI epidemiology is crucial for effective public health strategies.
Purpose of the Study:
- To characterize the distribution of Clostridioides difficile ribotypes in Las Vegas.
- To compare local CDI epidemiology with national surveillance data.
- To identify potential novel or underreported ribotypes in the region.
Main Methods:
- Stool samples were collected from adult patients diagnosed with CDI at the University Medical Center (UMC).
- Clostridioides difficile was isolated and ribotyped.
- Demographic data and patient histories were analyzed and compared with CDC surveillance data.
Main Results:
- The hypervirulent Clostridioides difficile strain 027 was the most prevalent ribotype.
- Four novel ribotypes (160, 302, 363, 813) were identified, not previously reported in human infections.
- Unique ribotype profiles were observed, differing from national surveillance data.
Conclusions:
- The study reveals a unique landscape of Clostridioides difficile ribotypes in Las Vegas.
- Findings provide critical insights into the circulating strains in a high-traffic tourist population.
- This data is valuable for understanding pre-COVID-19 CDI epidemiology in this unique setting.
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