Sertraline-Induced Sleep Paralysis: A Case Report.
Maninder Sohi1, Lakshit Jain2, Michael Ang-Rabanes1
1Psychiatry, West Virginia University School of Medicine, Martinsburg, USA.
Cureus
|November 29, 2023
Summary
Selective serotonin reuptake inhibitors (SSRIs) may cause isolated sleep paralysis in patients with major depressive disorder (MDD). This distressing side effect, though uncommon, warrants further investigation and consideration in clinical practice.
Area of Science:
- Neuroscience
- Psychiatry
Background:
- Major depressive disorder (MDD) significantly impacts sleep, often decreasing continuity and altering rapid eye movement (REM) sleep patterns.
- These sleep disturbances can persist post-treatment and are linked to depression recurrence.
- Antidepressant medications, particularly SSRIs, can influence REM sleep, with most patients reporting improved sleep, but some experiencing REM inhibition.
Observation:
- A case study involving a young patient with MDD who developed severe sleep paralysis after initiating sertraline treatment.
- The sleep paralysis episodes resolved upon tapering off the sertraline medication.
Findings:
- SSRIs may be associated with parasomnias, specifically isolated sleep paralysis, as an uncommon side effect.
- Isolated sleep paralysis is characterized by temporary inability to move during sleep onset or offset.
Implications:
- Clinicians should consider isolated sleep paralysis as a potential, albeit rare, adverse effect of SSRIs in patients with MDD.
- Further research is necessary to elucidate the precise relationship between SSRIs, sleep, and parasomnias.
- Clinical practice guidelines may need clarification regarding SSRI use and potential sleep-related side effects.
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