Related Experiment Video

Updated: Jul 9, 2025

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

16.5K

Effect of GH Deficiency Caused by Nonfunctioning Pituitary Masses on Serum C-reactive Protein Levels

Yasufumi Seki1, Satoshi Morimoto1, Kanako Bokuda1

  • 1Department of Internal Medicine, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.

Journal of the Endocrine Society
|November 29, 2023
PubMed

Insights

Growth hormone (GH) deficiency is linked to higher inflammation marker hs-CRP. Restoring GH secretion after pituitary surgery can reduce hs-CRP levels, indicating GH

Area of Science:

  • Endocrinology
  • Neuroendocrinology
  • Inflammation Research

Background:

  • Growth hormone (GH) deficiency (GHD) is associated with increased high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation.
  • The precise relationship between impaired GH secretion from pituitary masses and hs-CRP levels requires further elucidation.

Purpose of the Study:

  • To investigate the impact of impaired GH secretion, caused by pituitary masses, on hs-CRP levels.
  • To clarify the association between GH secretion and hs-CRP before and after pituitary surgery.

Main Methods:

  • Retrospective analysis of 171 patients with nonfunctioning pituitary neuroendocrine tumors or Rathke cleft cysts.
  • Assessment of GH secretion using GH-releasing peptide-2 and measurement of serum hs-CRP levels pre- and post-surgery.
  • Statistical analysis including correlation, multiple regression, and analysis of postoperative changes.

Main Results:

  • Severe GHD was present in 32% of patients and was associated with significantly higher hs-CRP levels (P < .001).
  • Peak GH levels negatively correlated with hs-CRP (r = -0.50, P < .001).
  • Lower peak GH predicted higher hs-CRP levels, and postoperative changes in peak GH predicted changes in hs-CRP.

Conclusions:

  • Impaired GH secretion due to pituitary masses is associated with elevated hs-CRP levels.
  • GH secretion plays a protective role against increased hs-CRP, suggesting a link between GH and inflammation.
Abstract

Keywords:
Rathke's cleft cysthypopituitarisminflammationpituitary neuroendocrine tumor

More Related Videos

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro07:51

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

6.0K
Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay07:14

Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Published on: June 16, 2023

2.7K

Related Concept Videos

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.2K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
96
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
423
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.6K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.2K